Ethmozine

Generic Name: moricizine (Oral route)

mor-I-si-zeen

Oral route(Tablet)

Considering the known proarrhythmic properties of moricizine and the lack of evidence of improved survival for any antiarrhythmic drug in patients without life-threatening arrhythmias, the use of moricizine, as well as other antiarrhythmic agents, should be reserved for patients with life-threatening ventricular arrhythmias .

Commonly used brand name(s)

In the U.S.

• Ethmozine

Available Dosage Forms:

• Tablet

Therapeutic Class: Antiarrhythmic, Group I

Uses For Ethmozine

Moricizine belongs to the group of medicines known as antiarrhythmics. It is used to correct irregular or rapid heartbeats to a normal rhythm by making the heart tissue less sensitive.

There is a chance that moricizine may cause new or make worse existing heart rhythm problems when it is used. Since other antiarrhythmic medicines have been shown to cause severe problems in some patients, moricizine is only used to treat serious heart rhythm problems. Discuss this possible effect with your doctor.

This medicine was available only with your doctor's prescription.

Effective August 28, 2007, the manufacturer will discontinue Ethmozine® (moricizine) due to lack of demand for the product. If you are taking moricizine right now, do not stop taking it or any other medicines until you have talked with your doctor. Your doctor may have special instructions for tapering you off of moricizine slowly. You or your doctor can contact the manufacturer at 1-800-828-2088 and choose the option "Medical Information" if you have questions .

Before Using Ethmozine

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Studies on this medicine have been done only in adult patients, and there is no specific information comparing use of moricizine in children with use in other age groups.

Geriatric

Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of moricizine in the elderly with use in other age groups, although the risk of some unwanted effects may be increased.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	B	Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Cisapride


• Sparfloxacin


• Thioridazine

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Amiodarone


• Amitriptyline


• Amoxapine


• Ciprofloxacin


• Clomipramine


• Desipramine


• Dofetilide


• Doxepin


• Gatifloxacin


• Ibutilide


• Imipramine


• Levofloxacin


• Lidocaine


• Moxifloxacin


• Norfloxacin


• Nortriptyline


• Ofloxacin


• Prilocaine


• Procainamide


• Protriptyline


• Sotalol


• Trimipramine


• Vardenafil

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Diltiazem


• Warfarin

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Kidney disease or


• Liver disease—Effects may be increased because of slower removal of moricizine from the body.

• Heart disease or


• Recent heart attack or


• If you have a pacemaker—Risk of irregular heartbeats may be increased.

Proper Use of Ethmozine

Take moricizine exactly as directed by your doctor, even though you may feel well. Do not take more or less of it than your doctor ordered.

This medicine works best when there is a constant amount in the blood. To help keep the amount constant, do not miss any doses. Also, it is best to take each dose at evenly spaced times day and night. For example, if you are to take 3 doses a day, doses should be spaced about 8 hours apart. If you need help in planning the best times to take your medicine, check with your health care professional.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral dosage form (tablets):
  
  • For irregular heartbeat (arrhythmias):
    
    • Adults—600 to 900 milligrams (mg) a day. This is divided into three doses and taken every eight hours.
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions While Using Ethmozine

It is important that your doctor check your progress at regular visits to make sure the medicine is working properly. This will allow changes to be made in the amount of medicine you are taking, if necessary.

Your doctor may want you to carry a medical identification card or bracelet stating that you are using this medicine.

Before having any kind of surgery (including dental surgery) or emergency treatment, tell the medical doctor or dentist in charge that you are taking this medicine.

Moricizine may cause some people to become dizzy or lightheaded. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy.

Ethmozine Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common

• Chest pain


• fast or irregular heartbeat


• shortness of breath


• swelling of the feet or lower legs

Rare

• Fever (sudden, high)

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Dizziness

Less common

• Blurred vision


• diarrhea


• dry mouth


• headache


• nausea or vomiting


• nervousness


• numbness or tingling in the arms or legs or around the mouth


• pain in the arms or legs


• stomach pain


• trouble with sleeping


• unusual tiredness or weakness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Ethmozine side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Ethmozine resources

• Ethmozine Side Effects (in more detail)
• Ethmozine Dosage
• Ethmozine Use in Pregnancy & Breastfeeding
• Drug Images
• Ethmozine Drug Interactions
• Ethmozine Support Group
• 1 Review for Ethmozine - Add your own review/rating

• Ethmozine Prescribing Information (FDA)


• Ethmozine Concise Consumer Information (Cerner Multum)


• Ethmozine MedFacts Consumer Leaflet (Wolters Kluwer)

Compare Ethmozine with other medications

• Ventricular Tachycardia

epirubicin

Generic Name: epirubicin (EP i ROO bi sin)

Brand names: Ellence, Pharmorubicin PFS, Pharmorubicin RDF

What is epirubicin?

Epirubicin is a cancer medication that interferes with the growth and spread of cancer cells in the body.

Epirubicin is used to treat breast cancer.

Epirubicin may also be used for purposes not listed in this medication guide.

What is the most important information I should know about epirubicin?

You should not use this medication if you are allergic to epirubicin or similar medications (Cerubidine, Adriamycin, Idamycin, Novantrone), or if you have an untreated or uncontrolled infection, severe liver disease, severe heart problems, or if you have recently had a heart attack. Epirubcin can have serious side effects on your heart. Before you are treated with epirubicin, tell your doctor if you have a history of heart disease, heart rhythm disorder, congestive heart failure, or heart attack.

Also tell your doctor about all other medicines you use, especially about any other cancer medications or treatments you have received (including radiation).

Do not use epirubicin if you are pregnant. It could harm the unborn baby. Epirubicin can lower blood cells that help your body fight infections. Your blood may need to be tested often. Avoid being near people who are sick or have infections. Avoid activities that may increase your risk of bleeding injury. Tell your doctor at once if you develop signs of infection. Do not receive a "live" vaccine while using epirubicin, or you could develop a serious infection.

Using epirubicin may increase your risk of developing other types of cancer, such as leukemia. Talk with your doctor about your specific risk.

What should I discuss with my healthcare provider before I receive epirubicin?

Before you are treated with epirubicin, tell your doctor about all other cancer medications and treatments you have received, including radiation. You should not use this medication if you are allergic to epirubicin or similar medications (Cerubidine, Adriamycin, Idamycin, Novantrone), or if you have:

• 
  

  an untreated or uncontrolled infection (including mouth sores);

  
  


• 
  

  severe liver disease;

  
  


• 
  

  severe heart problems; or

  
  


• 
  

  if you have recently had a heart attack.

  
  

To make sure you can safely receive epirubicin, tell your doctor if you have any of these other conditions:

• 
  

  liver or kidney disease;

  
  


• 
  

  a weak immune system caused by prior cancer treatments;

  
  


• 
  

  heart disease, a heart rhythm disorder, congestive heart failure; or

  
  


• 
  

  if you have ever had a heart attack.

  
  

Using epirubicin may increase your risk of developing other types of cancer, such as leukemia. Talk with your doctor about your specific risk. FDA pregnancy category D. Do not use epirubicin if you are pregnant. It could harm the unborn baby. Tell your doctor if you become pregnant or plan to become pregnant.

Use birth control to prevent pregnancy while you are receiving epirubicin, whether you are a man or a woman. Epirubicin use by either parent may cause birth defects.

It is not known whether epirubicin passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are using epirubicin.

How is epirubicin given?

Epirubicin is injected into a vein through an IV. You will receive this injection in a clinic or hospital setting. Epirubicin must be given slowly, and the IV infusion can take up to 20 minutes to complete.

Epirubicin is usually given together with other cancer medications. You may be given other medications to prevent nausea, vomiting, or infections.

Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when epirubicin is injected.

If any of this medication accidentally gets on your skin, wash it thoroughly with soap and warm water.

Epirubicin can lower blood cells that help your body fight infections. Your blood will need to be tested often. Your cancer treatments may be delayed based on the results of these tests. Visit your doctor regularly.

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your epirubicin injection.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include severe forms of some of the side effects listed in this medication guide.

What should I avoid while receiving epirubicin?

Do not receive a "live" vaccine while using epirubicin, or you could develop a serious infection. Live vaccines include measles, mumps, rubella (MMR), Bacillus Calmette-Guérin (BCG), oral polio, rotavirus, smallpox, typhoid, yellow fever, varicella (chickenpox), H1N1 influenza, and nasal flu vaccine.

Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.

Avoid activities that may increase your risk of bleeding or injury. Use extra care to prevent bleeding while shaving or brushing your teeth.

Epirubicin side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Tell your caregivers at once if you have a serious side effect such as:

• 
  

  pain, burning, irritation, or skin changes where the injection was given;

  
  


• 
  

  feeling short of breath, even with mild exertion;

  
  


• 
  

  swelling, rapid weight gain (especially in your face and midsection);

  
  


• 
  

  nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

  
  


• 
  

  fast, slow, or uneven heartbeats;

  
  


• 
  

  anxiety, sweating, severe shortness of breath, wheezing, gasping for breath;

  
  


• 
  

  chest pain, sudden cough, cough with foamy mucus, rapid breathing, coughing up blood;

  
  


• 
  

  lower back pain, blood in your urine, urinating less than usual or not at all;

  
  


• 
  

  numbness or tingly feeling around your mouth, weak pulse, overactive reflexes, confusion, fainting;

  
  


• 
  

  muscle weakness, tightness, or contraction;

  
  


• 
  

  fever, chills, body aches, flu symptoms, sores in your mouth and throat;

  
  


• 
  

  pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating; or

  
  


• 
  

  easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin.

  
  

Less serious side effects may include:

• 
  

  hot flashes, missed menstrual periods;

  
  


• 
  

  temporary hair loss;

  
  


• 
  

  feeling weak or tired;

  
  


• 
  

  mild nausea, diarrhea; or

  
  


• 
  

  eye redness, puffy eyelids.

  
  

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

Epirubicin Dosing Information

Usual Adult Dose for Breast Cancer -- Adjuvant:

For use as a component of adjuvant therapy in patients with evidence of axillary node tumor involvement following resection of primary breast cancer:

Starting Dose: 100 to 120 mg/m2 by intravenous infusion every 3 to 4 weeks. The total dose may either be given on Day 1 of each cycle or divided equally and given on Days 1 and 8 of each cycle.

What other drugs will affect epirubicin?

Many drugs can interact with epirubicin. Below is just a partial list. Tell your doctor if you are using:

• 
  

  acetaminophen (Tylenol);

  
  


• 
  

  auranofin (Ridaura) or gold injections to treat arthritis;

  
  


• 
  

  cimetidine (Tagamet);

  
  


• 
  

  rosiglitazone (Avandia, Avandamet, Avandaryl);

  
  


• 
  

  an antibiotic or antifungal medication;

  
  


• 
  

  an antidepressant such as amitriptyline (Elavil, Vanatrip, Limbitrol), doxepin (Sinequan, Silenor), nortriptyline (Pamelor), and others;

  
  


• 
  

  birth control pills or hormone replacement therapy;

  
  


• 
  

  cholesterol medications such as atorvastatin (Lipitor, Caduet), simvastatin (Zocor, Simcor, Vytorin), and others;

  
  


• 
  

  heart or blood pressure medicine such as amlodipine (Norvasc, Caduet, Exforge, Lotrel, Tekamlo, Tribenzor, Twynsta, Amturnide), atenolol (Tenormin, Tenoretic), carvedilol (Coreg), digoxin (Lanoxin), diltiazem (Cartia, Cardizem), enalapril (Vasotec), labetalol (Normodyne, Trandate), lisinopril (Prinivil, Zestril), methyldopa (Aldomet), nifedipine (Nifedical, Procardia), verapamil (Calan, Covera, Isoptin, Verelan, Tarka), and others;

  
  


• 
  

  HIV/AIDS medications;

  
  


• 
  

  an NSAID (non-steroidal anti-inflammatory drug) such as ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn, Naprelan, Treximet), celecoxib (Celebrex), diclofenac (Arthrotec, Cambia, Cataflam, Voltaren, Flector Patch, Pennsaid, Solareze), indomethacin (Indocin), meloxicam (Mobic), and others;

  
  


• 
  

  other cancer medications, especially docetaxel (Taxotere) or paclitaxel (Taxol, Onxol); or

  
  


• 
  

  seizure medications such as carbamazepine (Carbatrol, Equetro, Tegretol), divalproex (Depakote), phenobarbital (Solfoton), phenytoin (Dilantin), valproic acid (Depakene, Stavzor), and others.

  
  

This list is not complete and there may be other drugs that can interact with epirubicin. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

More epirubicin resources

• Epirubicin Side Effects (in more detail)
• Epirubicin Dosage
• Epirubicin Use in Pregnancy & Breastfeeding
• Epirubicin Drug Interactions
• Epirubicin Support Group
• 0 Reviews for Epirubicin - Add your own review/rating

• epirubicin Intravenous, Injection Advanced Consumer (Micromedex) - Includes Dosage Information


• Epirubicin MedFacts Consumer Leaflet (Wolters Kluwer)


• Epirubicin Prescribing Information (FDA)


• Ellence Prescribing Information (FDA)


• Ellence Monograph (AHFS DI)


• Ellence Consumer Overview

Compare epirubicin with other medications

• Breast Cancer, Adjuvant

Where can I get more information?

• Your doctor or pharmacist can provide more information about epirubicin.

See also: epirubicin side effects (in more detail)

Epinephrine Nebulizer Solution

Pronunciation: ep-i-NEF-rin
Generic Name: Epinephrine
Brand Name: Generic only. No brands available.

Epinephrine Nebulizer Solution is used for:

Treating shortness of breath, chest tightness, and wheezing associated with asthma, emphysema, and other breathing problems. It may also be used for other conditions as determined by your doctor.

Epinephrine Nebulizer Solution is an alpha- and beta-receptor stimulant. It works by widening the airway, which makes it easier to breathe.

Do NOT use Epinephrine Nebulizer Solution if:

• you are allergic to any ingredient in Epinephrine Nebulizer Solution

Contact your doctor or health care provider right away if any of these apply to you.

Before using Epinephrine Nebulizer Solution:

Some medical conditions may interact with Epinephrine Nebulizer Solution. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have taken furazolidone or a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) within the past 14 days


• if you have an overactive thyroid, urinary problems, an enlarged prostate, diabetes, high blood pressure, ischemic heart disease, an irregular heartbeat, or other heart problems

Some MEDICINES MAY INTERACT with Epinephrine Nebulizer Solution. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Beta-blockers (eg, propranolol), droxidopa, or phenothiazines (eg, chlorpromazine) because the risk of high or low blood pressure and fast or slow heartbeat may be increased


• Bromocriptine, furazolidone, MAOIs (eg, phenelzine), or tricyclic antidepressants (eg, amitriptyline) because the risk of side effects, such as headache, high temperature, and high blood pressure, may be increased


• Catechol-O-methyltransferase (COMT) inhibitors (eg, entacapone), digoxin, or medicines for irregular heartbeat (eg, quinidine) because they may increase the risk of Epinephrine Nebulizer Solution's side effects


• Guanethidine because its effectiveness may be decreased by Epinephrine Nebulizer Solution

This may not be a complete list of all interactions that may occur. Ask your health care provider if Epinephrine Nebulizer Solution may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Epinephrine Nebulizer Solution:

Use Epinephrine Nebulizer Solution as directed by your doctor. Check the label on the medicine for exact dosing instructions. Check the label on the medicine for exact dosing instructions.

• If the medicine turns pink to brown in color or is cloudy, do not use it.


• Epinephrine Nebulizer Solution is only for use by oral inhalation through a breathing machine (nebulizer). Carefully follow the procedures taught to you by your health care provider.


• If you miss a dose of Epinephrine Nebulizer Solution, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Epinephrine Nebulizer Solution.

Important safety information:

• Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.


• If your symptoms do not get better or if they get worse, check with your doctor.


• Epinephrine Nebulizer Solution may cause dry mouth or an unpleasant taste in your mouth. Rinsing your mouth with water after each dose may help relieve these effects.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Epinephrine Nebulizer Solution while you are pregnant. Epinephrine Nebulizer Solution is found in breast milk. If you are or will be breast-feeding while you use Epinephrine Nebulizer Solution, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Epinephrine Nebulizer Solution:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Difficulty sleeping; fast heartbeat; headache; loss of appetite; nausea; nervousness; tremors.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); wheezing.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include headache; irregular heartbeat; nausea; tremor; vomiting; weakness.

Proper storage of Epinephrine Nebulizer Solution:

Store Epinephrine Nebulizer Solution at room temperature, between 36 and 68 degrees F (2 and 20 degrees C). Store away from heat, moisture, and light. Keep Epinephrine Nebulizer Solution out of the reach of children and away from pets.

General information:

• If you have any questions about Epinephrine Nebulizer Solution, please talk with your doctor, pharmacist, or other health care provider.


• Epinephrine Nebulizer Solution is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Epinephrine Nebulizer Solution. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Epinephrine resources

• Epinephrine Use in Pregnancy & Breastfeeding
• Epinephrine Drug Interactions
• Epinephrine Support Group
• 11 Reviews for Epinephrine - Add your own review/rating

Compare Epinephrine with other medications

• Adams-Stokes Syndrome
• Allergic Reactions
• Asthma, acute
• Asystole
• AV Heart Block
• COPD, Acute
• Electromechanical Dissociation
• Shock

Equate Children's Ibuprofen - Berry - Dye Free

Generic Name: ibuprofen (Oral route)

eye-bue-PROE-fen

Oral route(Tablet;Suspension;Capsule, Liquid Filled;Tablet, Chewable)

NSAIDs may cause an increased risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, which can be fatal. This risk may be increased in patients with cardiovascular disease or risk factors for cardiovascular disease. Ibuprofen is contraindicated for the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery. NSAIDs can also cause an increased risk of serious gastrointestinal adverse events especially in the elderly, including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal .

Commonly used brand name(s)

In the U.S.

• Addaprin


• Advil


• A-G Profen


• Bufen


• Genpril


• Haltran


• I-Prin


• Midol


• Motrin


• Nuprin


• Proprinal


• Q-Profen

In Canada

• Actiprofen


• Advil Children's


• Advil Pediatric


• Children's Motrin


• Children's Motrin Berry Flavor


• Children's Motrin Bubble Gum Flavor


• Children's Motrin Grape Flavor


• Equate Children's Ibuprofen - Berry - Dye Free


• Infants' Motrin


• Teddy's Choice Children's Ibuprofen - Berry


• Teddy's Choice Children's Ibuprofen - Bubble Gum


• Teddy's Choice Children's Ibuprofen - Grape

Available Dosage Forms:

• Suspension


• Tablet


• Capsule, Liquid Filled


• Tablet, Chewable


• Capsule

Therapeutic Class: Analgesic

Pharmacologic Class: NSAID

Chemical Class: Propionic Acid (class)

Uses For Equate Children's Ibuprofen - Berry - Dye Free

Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) used to treat mild to moderate pain, and helps to relieve symptoms of arthritis (osteoarthritis, rheumatoid arthritis, or juvenile arthritis), such as inflammation, swelling, stiffness, and joint pain. This medicine does not cure arthritis and will help you only as long as you continue to take it .

In addition, ibuprofen can be used to treat fever, menstrual cramps, and other conditions as determined by your doctor .

This medicine is available both over-the-counter (OTC) and with your doctor's prescription .

Before Using Equate Children's Ibuprofen - Berry - Dye Free

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of ibuprofen in children below 6 months of age. Safety and efficacy have not been established .

Geriatric

Appropriate studies performed to date have not demonstrated geriatrics-specific problems that would limit the usefulness of ibuprofen in the elderly. However, elderly patients are more likely to have age-related kidney problems, which may require adjustment of dosage in patients receiving ibuprofen .

Pregnancy

	Pregnancy Category	Explanation
1st Trimester	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.
2nd Trimester	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.
3rd Trimester	D	Studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk.

Breast Feeding

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Ketorolac


• Pentoxifylline

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Abciximab


• Ardeparin


• Argatroban


• Beta Glucan


• Bivalirudin


• Certoparin


• Cilostazol


• Citalopram


• Clopidogrel


• Clovoxamine


• Dabigatran Etexilate


• Dalteparin


• Danaparoid


• Desirudin


• Dipyridamole


• Enoxaparin


• Escitalopram


• Femoxetine


• Flesinoxan


• Fluoxetine


• Fluvoxamine


• Fondaparinux


• Ginkgo


• Heparin


• Lepirudin


• Methotrexate


• Nadroparin


• Nefazodone


• Parnaparin


• Paroxetine


• Pemetrexed


• Protein C


• Reviparin


• Rivaroxaban


• Sertraline


• Sibutramine


• Tacrolimus


• Ticlopidine


• Tinzaparin


• Tirofiban


• Vilazodone


• Zimeldine

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Acebutolol


• Acetohexamide


• Alacepril


• Alprenolol


• Amikacin


• Amiloride


• Arotinolol


• Aspirin


• Atenolol


• Azilsartan Medoxomil


• Azosemide


• Befunolol


• Bemetizide


• Benazepril


• Bendroflumethiazide


• Benzthiazide


• Betaxolol


• Bevantolol


• Bisoprolol


• Bopindolol


• Bucindolol


• Bumetanide


• Bupranolol


• Buthiazide


• Candesartan Cilexetil


• Canrenoate


• Captopril


• Carteolol


• Carvedilol


• Celiprolol


• Chlorothiazide


• Chlorpropamide


• Chlorthalidone


• Cilazapril


• Clopamide


• Cyclopenthiazide


• Cyclosporine


• Delapril


• Desipramine


• Desvenlafaxine


• Dilevalol


• Duloxetine


• Enalaprilat


• Enalapril Maleate


• Eprosartan


• Esmolol


• Ethacrynic Acid


• Fosinopril


• Furosemide


• Gliclazide


• Glimepiride


• Glipizide


• Gliquidone


• Glyburide


• Hydrochlorothiazide


• Hydroflumethiazide


• Imidapril


• Indapamide


• Irbesartan


• Labetalol


• Landiolol


• Levobetaxolol


• Levobunolol


• Lisinopril


• Lithium


• Losartan


• Mepindolol


• Methyclothiazide


• Metipranolol


• Metolazone


• Metoprolol


• Milnacipran


• Moexipril


• Nadolol


• Nebivolol


• Nipradilol


• Olmesartan Medoxomil


• Oxprenolol


• Penbutolol


• Pentopril


• Perindopril


• Phenytoin


• Pindolol


• Piretanide


• Polythiazide


• Propranolol


• Quinapril


• Ramipril


• Sotalol


• Spirapril


• Spironolactone


• Tacrine


• Talinolol


• Tasosartan


• Telmisartan


• Temocapril


• Tertatolol


• Timolol


• Tolazamide


• Tolbutamide


• Torsemide


• Trandolapril


• Triamterene


• Trichlormethiazide


• Valsartan


• Venlafaxine


• Voriconazole


• Xipamide


• Zofenopril

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Anemia or


• Asthma or


• Bleeding problems or


• Blood clots or


• Edema (fluid retention or body swelling) or


• Heart attack, history of or


• Heart disease (e.g., congestive heart failure) or


• High blood pressure or


• Kidney disease or


• Liver disease (e.g., hepatitis) or


• Stomach or intestinal ulcers or bleeding or


• Stroke, history of—Use with caution. This medicine may make these conditions worse .

• Aspirin sensitivity, history of—This medicine should NOT be used in patients with this condition .

• Diabetes—Use with caution. The suspension form of this medicine contains sugar .

• Heart surgery (e.g., coronary artery bypass graft [CABG] surgery)—This medicine should NOT be used to relieve pain right before or after the surgery .

Proper Use of ibuprofen

This section provides information on the proper use of a number of products that contain ibuprofen. It may not be specific to Equate Children's Ibuprofen - Berry - Dye Free. Please read with care.

For safe and effective use of this medicine, do not take more of it, do not take it more often, and do not take it for a longer time than ordered by your doctor. Taking too much of this medicine may increase the chance of unwanted effects, especially in elderly patients .

When used for severe or continuing arthritis, this medicine must be taken regularly as ordered by your doctor in order for it to help you. This medicine usually begins to work within one week, but in severe cases up to two weeks or even longer may pass before you begin to feel better. Also, several weeks may pass before you feel the full effects of this medicine .

To lessen stomach upset, you may take this medicine with food or milk .

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral dosage form (tablets and suspension):
  
  • For fever:
    
    • Children over 2 years of age—Use and dose must be determined by your doctor.
    
    
    • Children 6 months of age up to 2 years—Dose is based on body weight and body temperature, and must be determined by your doctor. For fever lower than 102.5 °F (39.2 °C), the dose usually is 5 milligrams (mg) per kilogram (kg) (about 2.2 mg per pound) of body weight. For higher fever, the dose usually is 10 mg per kg (about 4.5 mg per pound) of body weight. The medicine may be given every six to eight hours, as needed, up to 40 mg per kg per day.
    
    
    • Infants younger than 6 months of age—Use and dose must be determined by your doctor .
    
    
  
  
  • For menstrual cramps:
    
    • Adults—400 milligrams (mg) every four hours, as needed.
    
    
    • Children—Use and dose must be determined by your doctor .
    
    
  
  
  • For mild to moderate pain:
    
    • Adults and teenagers—400 milligrams (mg) every four to six hours, as needed.
    
    
    • Children over 6 months of age—Dose is based on body weight and must be determined by your doctor. The dose usually is 10 milligrams (mg) per kilogram (kg) of body weight every six to eight hours, as needed, up to 40 mg per kg per day.
    
    
    • Infants younger than 6 months of age—Use and dose must be determined by your doctor .
    
    
  
  
  • For osteoarthritis and rheumatoid arthritis:
    
    • Adults and teenagers—1200 milligrams (mg) up to 3200 mg per day divided into three or four equal doses.
    
    
    • Children—Dose is based on body weight and must be determined by your doctor. The dose usually is 30 milligrams (mg) to 40 mg per kilogram (kg) of body weight per day, divided into three or four doses.
    
    
    • Infants younger than 6 months of age—Use and dose must be determined by your doctor .
    
    
  
  

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions While Using Equate Children's Ibuprofen - Berry - Dye Free

It is very important that your doctor check your progress at regular visits. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it. Blood and urine tests may be needed to check for unwanted effects .

This medicine may raise your risk of having a heart attack or stroke. This is more likely in people who already have heart disease. People who use this medicine for a long time might also have a higher risk .

This medicine may cause bleeding in your stomach or intestines. These problems can happen without warning signs. This is more likely if you have had a stomach ulcer in the past, if you smoke or drink alcohol regularly, if you are over 60 years old, if you are in poor health, or if you are using certain other medicines (a steroid or a blood thinner) .

Serious skin reactions can occur during treatment with this medicine. Check with your doctor right away if you have any of the following symptoms while taking this medicine: blistering, peeling, loosening of skin, chills, cough, diarrhea, fever, itching, joint or muscle pain, red skin lesions, sore throat, sores, ulcers, white spots in mouth or on lips, or unusual tiredness or weakness .

Possible warning signs of some serious side effects that can occur during treatment with this medicine may include swelling of the face, fingers, feet, and/or lower legs; severe stomach pain, black, tarry stools, and/or vomiting of blood or material that looks like coffee grounds; unusual weight gain; yellow skin or eyes; decreased urination; bleeding or bruising; and/or skin rash. Also, signs of serious heart problems could occur such as chest pain, tightness in chest, fast or irregular heartbeat, unusual flushing or warmth of skin, weakness, or slurring of speech. Stop taking this medicine and check with your doctor immediately if you notice any of these warning signs .

This medicine may also cause a serious type of allergic reaction called anaphylaxis. Although this is rare, it may occur often in patients who are allergic to aspirin or other nonsteroidal anti-inflammatory drugs. Anaphylaxis requires immediate medical attention. The most serious signs of this reaction are very fast or irregular breathing, gasping for breath, wheezing, or fainting. Other signs may include changes in skin color of the face; very fast but irregular heartbeat or pulse; hive-like swellings on the skin; and puffiness or swelling of the eyelids or around the eyes. If these effects occur, get emergency help at once .

Some people who have used this medicine had symptoms of meningitis. If you have fever, headache, nausea, vomiting, and stiff neck or back while using this medicine, check with your doctor right away .

Using this medicine while you are pregnant can harm your unborn baby. If you think you have become pregnant while using this medicine, tell your doctor right away .

Check with your doctor immediately if blurred vision, difficulty in reading, or any other change in vision occurs during or after your treatment. Your doctor may want you to have your eyes checked by an ophthalmologist (eye doctor) .

Before having any kind of surgery or medical tests, tell your doctor that you are taking this medicine. It may be necessary for you to stop treatment for a while, or to change to a different nonsteroidal anti-inflammatory drug before your procedure .

Equate Children's Ibuprofen - Berry - Dye Free Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

• Abdominal pain


• acid or sour stomach


• belching


• bloating


• cloudy urine


• decrease in amount of urine


• decrease in urine output or decrease in urine-concentrating ability


• diarrhea


• difficulty having a bowel movement (stool)


• excess air or gas in stomach or intestines


• full feeling


• heartburn


• indigestion


• itching skin


• pain or discomfort in chest, upper stomach, or throat


• pale skin


• passing gas


• nausea


• noisy, rattling breathing


• rash with flat lesions or small raised lesions on the skin


• shortness of breath


• swelling of face, fingers, hands, feet, lower legs, or ankles


• troubled breathing at rest


• troubled breathing with exertion


• unusual bleeding or bruising


• unusual tiredness or weakness


• vomiting


• weight gain

Less common

• Abdominal cramps


• stomach soreness or discomfort

Rare

• Agitation


• back, leg, or stomach pains


• bleeding gums


• blistering, peeling, loosening of skin


• blood in urine or stools


• bloody, black, or tarry stools


• blurred vision


• burning feeling in chest or stomach


• change in vision


• chest pain


• chills


• clay-colored stools


• coma


• confusion


• constipation


• cough or hoarseness


• dark urine


• decreased urine output


• depression


• difficulty breathing


• difficulty swallowing


• dilated neck veins


• dizziness


• dry mouth


• extreme fatigue


• fast, irregular, pounding, or racing heartbeat or pulse


• fever with or without chills


• frequent urination


• general body swelling


• general feeling of tiredness or weakness


• hair loss, thinning of hair


• headache


• hives or welts


• hostility


• impaired vision


• increased blood pressure


• increased volume of pale, dilute urine


• irregular breathing


• irritability


• itching


• joint or muscle pain


• lab results that show problems with liver


• lethargy


• light-colored stools


• loss of appetite


• lower back or side pain


• muscle twitching


• nosebleeds


• painful or difficult urination


• pains in stomach, side, or abdomen, possibly radiating to the back


• pinpoint red spots on skin


• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue


• rash


• red skin lesions, often with a purple center


• red, irritated eyes


• redness of skin


• seizures


• severe abdominal pain, cramping, burning


• severe and continuing nausea


• sore throat


• sores, ulcers, or white spots in mouth or on lips


• stiff neck or back


• stomach upset


• stupor


• swollen or painful glands


• tenderness in stomach area


• thirst


• tightness in chest


• unpleasant breath odor


• upper right abdominal pain


• vomiting of blood


• vomiting of material that looks like coffee grounds


• wheezing


• yellow eyes and skin

Symptoms of overdose

• Bluish lips or skin


• difficulty sleeping


• disorientation


• dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly


• drowsiness to profound coma


• hallucination


• lightheadedness or fainting


• mood or other mental changes


• muscle tremors


• not breathing


• rapid, deep breathing


• restlessness


• slow or irregular heartbeat


• stomach cramps


• sudden fainting


• sweating

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Continuing ringing or buzzing or other unexplained noise in ears


• hearing loss


• nervousness

Rare

• Crying


• depersonalization


• discouragement


• dry eyes


• dysphoria


• euphoria


• feeling sad or empty


• lack of appetite


• loss of interest or pleasure


• mental depression


• paranoia


• quick to react or overreact


• rapidly changing moods


• runny nose


• sleepiness or unusual drowsiness


• sleeplessness


• sneezing


• stuffy nose


• trouble concentrating


• trouble sleeping


• unable to sleep

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Equate Children's Ibuprofen - Berry - Dye Free side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Equate Children's Ibuprofen - Berry - Dye Free resources

• Equate Children's Ibuprofen - Berry - Dye Free Side Effects (in more detail)
• Equate Children's Ibuprofen - Berry - Dye Free Use in Pregnancy & Breastfeeding
• Drug Images
• Equate Children's Ibuprofen - Berry - Dye Free Drug Interactions
• Equate Children's Ibuprofen - Berry - Dye Free Support Group
• 51 Reviews for Equate Children's Ibuprofen - Berry - Dye Free - Add your own review/rating

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Eptifibatide

Pronunciation: ep-ti-FIB-ih-tide
Generic Name: Eptifibatide
Brand Name: Integrilin

Eptifibatide is used for:

Treating unstable angina (chest pain) or certain types of heart attacks. It may also be used to treat patients undergoing a certain type of procedure (percutaneous coronary intervention [PCI]). It may also be used to treat certain conditions as determined by your doctor that may not be listed in the professional package insert.

Eptifibatide is a platelet aggregation inhibitor. It works by preventing blood platelets from sticking together and forming blood clots.

Do NOT use Eptifibatide if:

• you are allergic to any ingredient in Eptifibatide


• you have a history of bleeding problems, active bleeding within the past 30 days, stroke or bleeding in the brain, or major surgery or severe injury within the past 6 weeks


• you have uncontrolled severe high blood pressure or if you must have kidney dialysis


• you are or will be taking another medicine similar to this one

Contact your doctor or health care provider right away if any of these apply to you.

Before using Eptifibatide:

Some medical conditions may interact with Eptifibatide. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have kidney problems or high serum creatinine levels, high blood pressure, or low blood platelet levels (eg, thrombocytopenia)

Some MEDICINES MAY INTERACT with Eptifibatide. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Anticoagulants (eg, warfarin, heparin), aspirin, dipyridamole, nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen), or thrombolytics (eg, alteplase) because risk of bleeding may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Eptifibatide may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Eptifibatide:

Use Eptifibatide as directed by your doctor. Check the label on the medicine for exact dosing instructions. Check the label on the medicine for exact dosing instructions.

• Eptifibatide will be administered as an injection at a hospital. Ask your doctor any questions that you may have about Eptifibatide.


• If you miss a dose of Eptifibatide, contact your doctor right away.

Ask your health care provider any questions you may have about how to use Eptifibatide.

Important safety information:

• Eptifibatide may reduce the number of blood cells that are needed for clotting. To prevent bleeding, avoid situations where bruising or injury may occur. Report any unusual bleeding, bruising, blood in stools, or dark tarry stools to your doctor.


• After using Eptifibatide, your doctor may prescribe other medicines to continue your treatment at home. If so, be sure to fill your prescriptions promptly.


• Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using Eptifibatide.


• LAB TESTS, including platelet counts, blood cell counts, and serum creatinine levels, will be performed to monitor your progress. Be sure to keep all doctor and lab appointments.


• Use Eptifibatide with caution in the ELDERLY because they may be more sensitive to its effects, especially the risk of bleeding.


• Eptifibatide is not recommended for use in CHILDREN; safety and effectiveness have not been confirmed.


• PREGNANCY and BREAST-FEEDING: If you plan on becoming pregnant, discuss with your doctor the benefits and risks of using Eptifibatide during pregnancy. It is unknown if Eptifibatide is excreted in breast milk. If you are or will be breast-feeding while you are using Eptifibatide, check with your doctor or pharmacist to discuss the risks to your baby.

Possible side effects of Eptifibatide:

All medicines may cause side effects, but many people have no, or minor, side effects. When used in small doses, no COMMON side effects have been reported with this product. Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry stools; bleeding from gums when brushing or flossing teeth; coughing up blood; excessive bleeding from cuts; increased menstrual bleeding; major bleeding episodes; nosebleeds; one-sided weakness; red urine; redness or pain after an injection; severe headache; stomach pain or swelling; unexplained vaginal bleeding; unusual bruising; vision or speech changes; vomiting blood or material that looks like coffee grounds.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Eptifibatide side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Eptifibatide:

Vials should be stored refrigerated at 36 to 46 degrees F (2 to 8 degrees C). Protect from light until time of use. Vials may be stored at room temperature between 59 and 86 degrees F (15 and 30 degrees C) for a period of 2 months or less. Do not use past the expiration date. Discard any unused portion left in the vial. Keep Eptifibatide out of the reach of children and away from pets.

General information:

• If you have any questions about Eptifibatide, please talk with your doctor, pharmacist, or other health care provider.


• Eptifibatide is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Eptifibatide. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Eptifibatide resources

• Eptifibatide Side Effects (in more detail)
• Eptifibatide Use in Pregnancy & Breastfeeding
• Eptifibatide Drug Interactions
• Eptifibatide Support Group
• 1 Review for Eptifibatide - Add your own review/rating

• Eptifibatide Professional Patient Advice (Wolters Kluwer)


• Eptifibatide Monograph (AHFS DI)


• eptifibatide Intravenous Advanced Consumer (Micromedex) - Includes Dosage Information


• Integrilin Prescribing Information (FDA)


• Integrilin Consumer Overview

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etoposide

Generic Name: etoposide (oral) (ee TOW poh side)

Brand names: VePesid, Etopophos (obsolete), Toposar

What is etoposide?

Etoposide is a cancer medicine that interferes with the growth of cancer cells and slows their growth and spread in the body.

Etoposide is used to treat cancer of the lung or testicles.

Etoposide may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about etoposide?

Do not use this medication without your doctor's consent if you are pregnant. It could cause harm to the unborn baby. Use an effective form of birth control, and tell your doctor if you become pregnant during treatment. Do not break or open an etoposide capsule. The medicine from a broken capsule can be dangerous if it gets in your eyes, mouth, or nose, or on your skin. If skin contact occurs, wash the area with soap and water or rinse the eyes thoroughly with plain water. If you must handle a broken capsule, ask your doctor or pharmacist how to safely dispose of the capsule.

Etoposide can lower the blood cells that help your body fight infections. This can make it easier for you to bleed from an injury or get sick from being around others who are ill. To be sure your blood cells do not get too low, your blood will need to be tested on a regular basis. It is important that you not miss any scheduled visits to your doctor.

Using etoposide may increase your risk of developing other types of cancer, such as leukemia. Talk with your doctor about your specific risk.

What should I discuss with my healthcare provider before taking etoposide?

Before using etoposide, tell your doctor if you have:

• kidney disease; or


• 
  

  a weak immune system (from disease or from taking certain medicines).

  
  

If you have any of these conditions, you may not be able to use etoposide, or you may need a dosage adjustment or special tests during treatment.

FDA pregnancy category D. This medication can cause harm to an unborn baby. Do not use etoposide without your doctor's consent if you are pregnant. Tell your doctor if you become pregnant during treatment. Use an effective form of birth control while you are using this medication. It is not known whether etoposide passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Using etoposide may increase your risk of developing other types of cancer, such as leukemia. Talk with your doctor about your specific risk.

How should I use etoposide?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor.

Take each dose with a full glass of water. Do not break or open an etoposide capsule. The medicine from a broken capsule can be dangerous if it gets in your eyes, mouth, or nose, or on your skin. If skin contact occurs, wash the area with soap and water or rinse the eyes thoroughly with plain water. If you must handle a broken capsule, ask your doctor or pharmacist how to safely dispose of the capsule.

Etoposide can lower the blood cells that help your body fight infections. This can make it easier for you to bleed from an injury or get sick from being around others who are ill. To be sure your blood cells do not get too low, your blood will need to be tested on a regular basis. It is important that you not miss any scheduled visits to your doctor.

Store etoposide capsules in the refrigerator. Do not allow them to freeze.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine. Symptoms of an etoposide overdose may include severe nausea and vomiting, fever, chills, sore throat, flu symptoms, easy bruising, or extreme weakness.

What should I avoid while using etoposide?

Avoid contact with people who have colds, the flu, or other contagious illnesses. Contact your doctor immediately if you develop signs of infection.

Do not receive a "live" vaccine while you are being treated with etoposide.

Etoposide side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects:

• 
  

  fever, chills, body aches, flu symptoms;

  
  


• 
  

  white patches or sores inside your mouth or on your lips;

  
  


• 
  

  easy bruising or bleeding, unusual weakness;

  
  


• 
  

  fast heart rate;

  
  


• 
  

  severe nausea and vomiting;

  
  


• 
  

  feeling light-headed, fainting; or

  
  


• 
  

  low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

  
  

Other, less serious side effects may be more likely to occur, such as:

• 
  

  mild nausea, vomiting, stomach pain;

  
  


• 
  

  mild itching or skin rash; or

  
  


• 
  

  temporary hair loss.

  
  

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

Etoposide Dosing Information

Usual Adult Dose for Testicular Cancer:

(In combination with other approved chemotherapeutic agents) Initial dose: 50 to 100 mg/m² IV once a day on days 1 through 5 or 100 mg/m2 IV once a day on days 1,3 and 5.

Usual Adult Dose for Small Cell Lung Cancer:

(In combination with other approved chemotherapeutic agents) Initial dose: 35 to 50 mg/m2 IV once a day for 4 to 5 days or
70 to 100 mg/m2 orally once a day for 4 to 5 days.

Usual Adult Dose for Hodgkin's Disease:

(In combination with other chemotherapeutic agents as a part of the BEACOPP and EVA regimens)
100 mg/m2/day on days 1, 2, and 3
Total Dose/Cycle = 300 mg/m2

(In combination with other chemotherapeutic agents as a part of the mini-BEAM regimen)
75 mg/m2/day on days 2 through 5
Total Dose/Cycle = 300 mg/m2

(In combination with other chemotherapeutic agents as a part of the Stanford V regimen)
60 mg/m2/day on days 15 and 16
Total Dose/Cycle = 120 mg/m2

Usual Adult Dose for Ovarian Cancer:

For use in the treatment of epithelial ovarian cancer:
50 mg/m2 daily on days 1 through 21

For use in the treatment of germ cell ovarian cancer:
(In combination with other approved chemotherapeutic agents as a part of the BEP regimen)
100 mg/m2 IV on days 1 through 5

Usual Geriatric Dose for Testicular Cancer:

The manufacturer has stated that clinical studies of etoposide for the treatment of refractory testicular tumors did not include sufficient numbers of patients aged 65 years or over to determine if they respond differently from younger patients.

Usual Pediatric Dose for Malignant Disease:

Note: Oral doses are twice the IV doses listed below. Oral doses are to be administered once a day if
60 to 150 mg/m2/day IV for 2 to 5 days every 3 to 6 weeks.

Remission induction for AML: 150 mg/m2/day IV for 2 to 3 days for 2 to 3 cycles.

Intensification/Consolidation for AML: 250 mg/m2/day IV for 3 days, courses 2 to 5.

Brain Tumor: 150 mg/m2/day IV on days 2 and 3.

Neuroblastoma: 100 mg/m2/day IV over 1 hour on days 1
through 5 of the cycle, repeated every 4 weeks.

High-dose conditioning regimen for allogenic BMT: 60 mg/kg/dose IV as a single dose.

BMT conditioning regimen used in patients with rhabdomyosarcoma or neuroblastoma: IV continuous infusion: 160 mg/m2/day for 4 days.

What other drugs will affect etoposide?

Before using etoposide, tell your doctor if you are using cyclosporine (Neoral, Sandimmune, Gengraf).

There may be other drugs that can affect etoposide. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

More etoposide resources

• Etoposide Side Effects (in more detail)
• Etoposide Dosage
• Etoposide Use in Pregnancy & Breastfeeding
• Drug Images
• Etoposide Drug Interactions
• Etoposide Support Group
• 0 Reviews for Etoposide - Add your own review/rating

• etoposide Advanced Consumer (Micromedex) - Includes Dosage Information


• Etoposide Professional Patient Advice (Wolters Kluwer)


• Etoposide Prescribing Information (FDA)


• Etoposide MedFacts Consumer Leaflet (Wolters Kluwer)


• Etoposide Monograph (AHFS DI)


• Toposar Prescribing Information (FDA)


• VePesid Prescribing Information (FDA)


• VePesid MedFacts Consumer Leaflet (Wolters Kluwer)


• Vepesid Advanced Consumer (Micromedex) - Includes Dosage Information

Compare etoposide with other medications

• Cancer
• Hodgkin's Lymphoma
• Ovarian Cancer
• Small Cell Lung Cancer
• Testicular Cancer

Where can I get more information?

• Your pharmacist has more information about etoposide written for health professionals that you may read.

See also: etoposide side effects (in more detail)

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